1 Subjects: “...Randomized Controlled Trials as Topic...”

2 “.... Evidence was generally consistent in direction of effect but with variable precision across studies...”

3 “...'s ability to produce valid results for two data scenarios when varying numbers of studies were available...”

4 “...'s ability to produce valid results for two data scenarios when varying numbers of studies were available...”

5

6

7 “...Although the decision changes were observed in both directions for individual patients, studies...”

8 “...Although the decision changes were observed in both directions for individual patients, studies...”

9 “... care practice setting...”

10 “... care practice setting...”

11 “... studies; n=76,856) and was over 80 percent in most studies. The specificity ranged from 26.4 to 99.7...”

12 “...We found no evidence on possible harms of these interventions. New studies that address a...”

13 “...We found no evidence on possible harms of these interventions. New studies that address a...”

14 “... quality for included studies using predefined criteria. DATA SYNTHESIS: One fair-quality trial...”

15 “... quality for included studies using predefined criteria. DATA SYNTHESIS: One fair-quality trial...”

16 “..., and observational studies do not clearly establish the magnitude of benefit. For women enrolled in WIC, low SOE...”

17 “..., and observational studies do not clearly establish the magnitude of benefit. For women enrolled in WIC, low SOE...”

18 “... are not available. Thus, studies estimated accuracy using patients with confirmed active TB to establish sensitivity...”

19 “... or harms of screening for AF because we identified no eligible studies that aimed to address...”

20 “...: This body of evidence was limited by imprecise effect estimates largely because studies were not powered...”