1

2

3 “... qualitative concordance based on a 2-tiered approach incorporating changes in statistical significance...”

4 “... qualitative concordance based on a 2-tiered approach incorporating changes in statistical significance...”

5 “...We did not quantitatively analyze our data because of statistical heterogeneity, insufficient...”

6 “...We did not quantitatively analyze our data because of statistical heterogeneity, insufficient...”

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8

9

10

11

12

13 “...However, risk (per 10,000 women over 5.4 to 7.1 years) was statistically significantly increased...”

14 “... on the association between folic acid supplementation and NTDs (N=990,372). One cohort study reported a statistically...”

15 “... in the risk-benefit profile between treatment formulations. Women using estrogen only had statistically...”

16

17 “... in the risk-benefit profile between treatment formulations. Women using estrogen only had statistically...”

18 “... no statistically significant difference between A-allele homozygotes and those with at least one G allele...”

19 “... no statistically significant difference between A-allele homozygotes and those with at least one G allele...”

20