1 “... it is asymptomatic. If it becomes symptomatic it can lead to significant impairment of quality of life through...”

2 “... it is asymptomatic. If it becomes symptomatic it can lead to significant impairment of quality of life through...”

3 “... decline in lung function, reduced quality of life and ultimately death. Specific pharmacological therapies...”

4 “... decline in lung function, reduced quality of life and ultimately death. Specific pharmacological therapies...”

5 “... is to abolish or minimise symptoms, and to improve quality of life and long-term morbidity and mortality....”

6

7

8 “..., as well as an adverse and often highly debilitating effect on their quality of life...”

9 “..., as well as an adverse and often highly debilitating effect on their quality of life...”

10

11