1 “.... The identified studies are small, with few events and risk of bias. Our confidence in estimates of clinical...”

2 “... hotel. Additionally, most studies included few patients and all of them had high risk of bias. Therefore...”

3 “... inclusion criteria. 2. The included studies had low methodological quality and a high risk of bias. 3. One...”

4 “..., and several of the studies have high risk of bias. We were asked to summarize studies that could say something...”

5 “.... There was inconsistency in the results and all conclusions were based on findings from studies with high risk of bias...”

6

7 “..., and the conclusions are based on findings from small studies with unclear or high risk of bias. It is important...”

8 “... therapeutic interventions. We can not rule out a possible publication bias in the material which means...”

9

10 “... risk of bias in the results. The evidence is therefore of too low quality to be able to judge whether...”

11

12 “... for downgrading were risk of bias and uncertainty about the transferability to individual populations.3. Eleven...”

13 “... and minimum bias, until earliest in 2009, when both registers have been in operation for one year. Partly due...”

14

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