1 “... number of new studies, the overall high risk of bias of many of these studies necessitated ratings of low...”

2 “... number of new studies, the overall high risk of bias of many of these studies necessitated ratings of low...”

3 “... to placebo (low-strength evidence). However, improvements were of modest clinical significance, with values...”

4 “... to placebo (low-strength evidence). However, improvements were of modest clinical significance, with values...”

5

6

7 “... one positive finding for a specific outcome, some reaching low strength of evidence, but these were...”

8 “... one positive finding for a specific outcome, some reaching low strength of evidence, but these were...”

9

10 “... of bias, resulting in low or insufficient evidence for all outcomes examined. In comparing AL with NH, low...”

11 “... of bias, resulting in low or insufficient evidence for all outcomes examined. In comparing AL with NH, low...”

12

13

14 “...BACKGROUND: Osteoporosis is a skeletal system disease characterized by low bone density...”

15 “... to topiramate monotherapy (low-strength evidence from one RCT of 191 adults). For episodic migraine, RCTs...”

16 “... to topiramate monotherapy (low-strength evidence from one RCT of 191 adults). For episodic migraine, RCTs...”

17

18

19 “... that addressed primary outcomes and were assessed to have a low or moderate risk of bias were graded to evaluate...”

20 “... that addressed primary outcomes and were assessed to have a low or moderate risk of bias were graded to evaluate...”