1 “...Therefore, we propose a framework that includes both the characterization of the gap using PICOS...”

2 “...Therefore, we propose a framework that includes both the characterization of the gap using PICOS...”

3 “... 1991 until January 2012. REVIEW METHODS: The review included original studies that applied a...”

4 “... 1991 until January 2012. REVIEW METHODS: The review included original studies that applied a...”

5

6

7 “...We have performed a systematic review of published studies on the comparative effectiveness...”

8 “...We have performed a systematic review of published studies on the comparative effectiveness...”

9 “... antidiabetic agents in terms of reducing fasting and postprandial glucose, A1c, microvascular and macrovascular...”

10 “... antidiabetic agents in terms of reducing fasting and postprandial glucose, A1c, microvascular and macrovascular...”

11 “... to interact directly with consumers, with or without the presence of a health care professional that provides...”

12 “... evaluation data? (2) When should economic evaluation data be requested in a systematic review? (3) Who...”

13 “... evaluation data? (2) When should economic evaluation data be requested in a systematic review? (3) Who...”

14 “... insufficient evidence to permit conclusions. CONCLUSIONS: Our systematic review demonstrates that there is a...”

15 “...Comparisons of two-drug combinations showed little to no difference in HbA1c reduction, but some...”

16 “... insufficient evidence to permit conclusions. CONCLUSIONS: Our systematic review demonstrates that there is a...”

17 “..., the technology used does not make a difference in pressure lowering. With regard to incisional surgeries...”

18 “..., the technology used does not make a difference in pressure lowering. With regard to incisional surgeries...”

19 “... reviewer abstracted information and completed risk-of-bias assessment, and this was verified by a second...”

20 “... reviewer abstracted information and completed risk-of-bias assessment, and this was verified by a second...”