1 “... consistency in comparator groups, robust randomized study designs, larger trials, and common definitions...”

2 “... consistency in comparator groups, robust randomized study designs, larger trials, and common definitions...”

3 “... field progression, and harms as well as sensitivity and specificity of tests. For studies and systematic...”

4 “... field progression, and harms as well as sensitivity and specificity of tests. For studies and systematic...”

5 “... or patient-reported outcomes. This should be an area of focus in future trials of adequate size and duration...”

6 “... or patient-reported outcomes. This should be an area of focus in future trials of adequate size and duration...”

7 “... of Controlled Trials, CINAHL(r), and PsycINFO(r) through June 2012 for published articles that were potentially...”

8 “... of Controlled Trials, CINAHL(r), and PsycINFO(r) through June 2012 for published articles that were potentially...”

9 “...RESULTS: We included 764 studies; 310 studies were included in our syntheses. Patients using...”

10 “... robust observational studies that control for confounding by indication and disease severity are needed...”

11 “... robust observational studies that control for confounding by indication and disease severity are needed...”

12 “... SOURCES: MEDLINE(r), Embase(r), and the Cochrane Central Register of Controlled Trials from inception...”

13 “... SOURCES: MEDLINE(r), Embase(r), and the Cochrane Central Register of Controlled Trials from inception...”

14 “...RESULTS: Our search retrieved over 10,000 articles. We included 60 studies (62 publications). Most...”

15 “...RESULTS: Our search retrieved over 10,000 articles. We included 60 studies (62 publications). Most...”

16

17 “...We identified 13 pediatric studies of subcutaneous immunotherapy, 18 pediatric studies...”

18 “...We identified 13 pediatric studies of subcutaneous immunotherapy, 18 pediatric studies...”

19 “... to usual care. We identified 125 QOL or symptom measure tools used in 165 studies. Ten tools were designed...”

20 “..., Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from May 2008 to July 2013 were...”