1 “... questionable in this age group, is likely to be countered by harm expected from overdiagnosis and consequences...”

2 “...RESEARCH QUESTION: The aim of the present investigation is the benefit assessment of the method...”

3

4

5 “... from a presymptomatic treatment start. Currently, it is therefore especially unclear how to handle...”

6 “... from a presymptomatic treatment start. Currently, it is therefore especially unclear how to handle...”

7 “... be assumed to be in place, which is, however, not entirely the case in view of the current lack of regulation....”

8 “... be assumed to be in place, which is, however, not entirely the case in view of the current lack of regulation....”

9

10