1

2 “...]) (pooled RR, 0.64 [95% CI, 0.46 to 0.90], k=7, n=1,522, I2 15.8.6%). Data on potential harms and adverse...”

3 “...]) (pooled RR, 0.64 [95% CI, 0.46 to 0.90], k=7, n=1,522, I2 15.8.6%). Data on potential harms and adverse...”

4

5 “... [MD], −0.94 [95% CI, −1.40 to −0.48]; I2 16%). There was not evidence of small study effects. Meta...”

6 “... [MD], −0.94 [95% CI, −1.40 to −0.48]; I2 16%). There was not evidence of small study effects. Meta...”

7

8

9

10

11

12

13 “... on more rounds of screening and larger study populations. Harms of screening in these two large screening...”

14 “... on more rounds of screening and larger study populations. Harms of screening in these two large screening...”

15 “...The 73 potentially relevant articles identified were then independently evaluated by two reviewers...”

16 “...The 73 potentially relevant articles identified were then independently evaluated by two reviewers...”