1 Subjects: “...Randomized Controlled Trials as Topic...”

2 “... in the included studies. For KQ4, 13 studies (N=5,150) suggest that screening is associated with no decrements...”

3 “...The smaller AMTEC trial (N=55) reported a statistically significantly lower composite risk...”

4 “...Based on eight heterogeneous, short-term rescreening studies (N=8,018) with a variety of protocols...”

5 “...Based on eight heterogeneous, short-term rescreening studies (N=8,018) with a variety of protocols...”

6 “... the diagnostic accuracy and harms of the routine screening pelvic examination to guide practice in asymptomatic...”

7 “... the diagnostic accuracy and harms of the routine screening pelvic examination to guide practice in asymptomatic...”

8 “...Two trials reported conflicting results on total or fatal hemorrhagic CVA risk with wide confidence...”

9 “...Two trials reported conflicting results on total or fatal hemorrhagic CVA risk with wide confidence...”

10 “...Based on pooled analysis of 11 primary CVD prevention trials using aspirin ≤100 mg/day, low-dose...”

11 “...Additionally, we re-evaluated all studies included in the 2010 review. We supplemented our searches...”

12 “...Additionally, we re-evaluated all studies included in the 2010 review. We supplemented our searches...”

13 “... of Controlled Trials (CENTRAL) from January 1, 2008, to January 16, 2018. STUDY SELECTION: We screened 282...”

14 “... of Controlled Trials (CENTRAL) from January 1, 2008, to January 16, 2018. STUDY SELECTION: We screened 282...”

15 “...One fair-quality study examined a staged approach whereby the screening test was considered...”

16 “...One fair-quality study examined a staged approach whereby the screening test was considered...”

17 “...'s effectiveness in reducing nonfatal MI/coronary events that were reported in trials of doses ranging from 100 mg...”