1 “... trials were concordant with pooled subsequent studies in at least 33 percent but up to 50 percent...”

2 Subjects: “...Clinical Trials as Topic...”

3

4

5 “...STUDY SELECTION: We dually reviewed the literature and included randomized, placebo-controlled...”

6 “...STUDY SELECTION: We dually reviewed the literature and included randomized, placebo-controlled...”

7

8 “... on diagnostic accuracy was limited to one poor quality study. Epidemiological studies determining associations...”

9 “... on diagnostic accuracy was limited to one poor quality study. Epidemiological studies determining associations...”

10

11 “... selected, extracted data from, and rated risk of bias of studies. We graded strength of evidence based...”

12 “... selected, extracted data from, and rated risk of bias of studies. We graded strength of evidence based...”