1 “... interaction results were reported in text; only two RCTs and five pooled RCT analyses displayed data...”

2 “... interaction results were reported in text; only two RCTs and five pooled RCT analyses displayed data...”

3 “... compared with a diverse group of LOCMs (pooled relative risk, 0.80; 95% confidence interval [CI], 0.65...”

4 “... compared with a diverse group of LOCMs (pooled relative risk, 0.80; 95% confidence interval [CI], 0.65...”

5 “... (pooled HR, 1.04; 95% CI, 0.99 to 1.10; I2 = 38%; 44 trials), but many trials did not include an overall...”

6 “... (pooled HR, 1.04; 95% CI, 0.99 to 1.10; I2 = 38%; 44 trials), but many trials did not include an overall...”

7

8

9

10

11 “... treatment was quantitatively examined using pooled analysis. Qualitative narrative analysis was used...”

12 “... pooled using a random effects model....”

13 “... pooled using a random effects model....”

14 “... evaluated and where possible, statistically pooled. For dichotomous endpoints, we used relative risks...”

15 “..., pooled data for analysis when appropriate and feasible, and evaluated strength of evidence...”

16 “... pooled effects. We graded strength of evidence (SOE) based on established guidance. RESULTS: We included...”

17 “..., pooled data for analysis when appropriate and feasible, and evaluated strength of evidence...”

18 “... pooled effects. We graded strength of evidence (SOE) based on established guidance. RESULTS: We included...”

19

20