1 “...Literature searches found no studies that met inclusion criteria and assessed effectiveness...”

2 “...Most studies did not report harms related to PGHD interventions; the relatively few harms reported...”

3 “...More RCTs and better designed observational studies that can control for many of the known...”

4 “...More RCTs and better designed observational studies that can control for many of the known...”

5 “...In the same sham-controlled trial, BT reduced severe exacerbations after the 12-week treatment...”

6 “...In the same sham-controlled trial, BT reduced severe exacerbations after the 12-week treatment...”

7 “... of alternative immunosuppressive drugs are not widely studied...”

8 “... of alternative immunosuppressive drugs are not widely studied...”

9 “... is inconclusive because of a lack of studies. Further research is needed examining well-defined (standardized...”

10 “... is inconclusive because of a lack of studies. Further research is needed examining well-defined (standardized...”

11

12