1 “... responsiveness. CONCLUSIONS: Few data are available to evaluate the comparative effectiveness of either specific...”

2 “...; treatment protocols had marked heterogeneity; and significant amounts of data about important outcomes...”

3 “...; treatment protocols had marked heterogeneity; and significant amounts of data about important outcomes...”

4

5

6 “... ability to predict mortality, and data on TAPSE were insufficient. Thirty-seven studies involving 4,192...”

7 “... ability to predict mortality, and data on TAPSE were insufficient. Thirty-seven studies involving 4,192...”

8 “... options, and overall assume that treatment options are equally effective for both sexes when gender data...”

9

10 “... options, and overall assume that treatment options are equally effective for both sexes when gender data...”

11

12

13 “... claudication (IC) or critical limb ischemia (CLI). DATA SOURCES: We searched PubMed(r), Embase(r...”

14

15 “... claudication (IC) or critical limb ischemia (CLI). DATA SOURCES: We searched PubMed(r), Embase(r...”

16 “... and at each followup time point--including subgroup data on important demographic and clinical factors...”

17 “... and at each followup time point--including subgroup data on important demographic and clinical factors...”

18 “... setting for individuals from birth through 17 years of age. DATA SOURCES: We searched PubMed(r), Embase(r...”

19 “... setting for individuals from birth through 17 years of age. DATA SOURCES: We searched PubMed(r), Embase(r...”

20 “... fibrillation. DATA SOURCES: We searched PubMed(r), Embase(r), and the Cochrane Database of Systematic Reviews...”