1 “... publications were included. Most trials enrolled patients with pain symptoms of at least moderate intensity...”

2 “...Synthetic products with high-THC to CBD ratios were associated with a moderate improvement in pain...”

3 “... publications were included. Most trials enrolled patients with pain symptoms of at least moderate intensity...”

4 “...% confidence interval [CI] −0.95 to −0.19, I2=39%; SOE: moderate) and a small decrease in overall function (6...”

5

6

7

8

9

10 “... difference [WMD] 7.55 on a 0 to 100 scale, 95% CI 11.4 to 3.74) (strength of evidence [SOE]: moderate), mean...”

11 “... difference [WMD] 7.55 on a 0 to 100 scale, 95% CI 11.4 to 3.74) (strength of evidence [SOE]: moderate), mean...”

12 “... questionnaires were associated with moderate diagnostic accuracy for periodontal disease; evidence...”

13

14

15

16 “... an opioid or nonopioid alone. Magnitude of effects was classified as small, moderate, or large using...”

17 “... an opioid or nonopioid alone. Magnitude of effects was classified as small, moderate, or large using...”

18

19

20