1

2 “... in populations, settings, and outcomes, and substantial statistical heterogeneity. Statistical heterogeneity...”

3

4 “... resulted in a slight increase in the C statistic compared with traditional risk factor assessment alone...”

5 “... resulted in a slight increase in the C statistic compared with traditional risk factor assessment alone...”

6 “..., and estimates were imprecise. Limitations included restriction to English-language articles, statistical...”

7 “..., and estimates were imprecise. Limitations included restriction to English-language articles, statistical...”

8

9

10