1

2 “...DATA EXTRACTION: One investigator extracted data on participants, study design, analysis, followup...”

3 “...DATA EXTRACTION: One investigator extracted data on participants, study design, analysis, followup...”

4 “... of the Institute of Medicine (IOM) recommendations (39 trials; RR, 0.83 [95% CI, 0.77 to 0.89]; I2=63.8%; ARD, −7.6...”

5

6 “.... STUDY SELECTION: English-language trials and observational studies of screening effectiveness, test...”

7 “.... STUDY SELECTION: English-language trials and observational studies of screening effectiveness, test...”

8

9

10 “...Two investigators independently applied prespecified criteria to rate study quality using methods...”

11 “...Two investigators independently applied prespecified criteria to rate study quality using methods...”

12

13

14 “...DATA EXTRACTION: One investigator abstracted details about each article's study design, patient...”

15 “...DATA EXTRACTION: One investigator abstracted details about each article's study design, patient...”