1 “... metabolite bind to [mu]-opioid receptors in the central nervous system resulting in inhibition of ascending...”

2 “... gamma aminobutyric acid (GABA) but does not bind to the GABA receptors. Its mechanism of action...”

3 “... gamma aminobutyric acid (GABA) but does not bind to the GABA receptors. Its mechanism of action...”

4

5

6 “... at least four migraine days monthly.It is a monoclonal antibody that binds to and inhibits calcitonin gene...”

7 “...-inflammatory by binding to the glucocorticoid receptor. Budesonide is formulated as a 1 mg orodispersible...”

8 “... mechanisms of action; specifically, daptomycin works by binding or inserting into the outer membrane, while...”

9 “... mechanisms of action; specifically, daptomycin works by binding or inserting into the outer membrane, while...”

10 “... that binds selectively to the interleukin 23 (IL-23) protein with high specificity and affinity. Levels of IL...”

11 “... the beneficial and harmful effects of GPB as a nitrogen-binding agent adjunctive to dietary protein restriction...”

12 “...Vedolizumab is a humanized immunoglobulin G1 monoclonal antibody that binds exclusively...”

13 “...Vedolizumab is a humanized immunoglobulin G1 monoclonal antibody that binds exclusively...”

14 “... antibody that binds to the N-terminal domain of FGF23. The Health Canada-recommended starting dose...”

15 “... antibody that binds to the N-terminal domain of FGF23. The Health Canada-recommended starting dose...”

16 “..., spinal instability, and compression of the spinal cord. Denosumab is a human monoclonal antibody binding...”

17 “... antibody that binds specifically to both soluble and membrane-bound interleukin-6 receptors inhibiting...”

18 “.... Nusinersen is an antisense oligonucleotide that binds to the SMN2 pre-messenger ribonucleic acid, this leads...”

19 “... or in combination with methotrexate. Ustekinumab is a fully human IgG1 kappa monoclonal antibody that binds...”

20 “... or in combination with methotrexate. Ustekinumab is a fully human IgG1 kappa monoclonal antibody that binds...”