1 “... biological mesh, absorbable synthetic mesh, and non-absorbable synthetic mesh. Biological meshes...”

2 “... biological mesh, absorbable synthetic mesh, and non-absorbable synthetic mesh. Biological meshes...”

3 “... and safety, as well as evidence-based clinical guidelines, on the practice of switching biologics, both...”

4 Subjects: “...Biological Products / therapeutic use...”

5 “... of biologics and immunomodulators among UC patients naïve to both types of drugs...”

6 Subjects: “...Biological Products / therapeutic use...”

7 Subjects: “...Biological Products / therapeutic use...”

8 “... and Submission Guidelines for Subsequent Entry Biologics (March, 2014). The CDR team reviewed the information...”

9 “... and Submission Guidelines for Subsequent Entry Biologics (March, 2014). The CDR team reviewed the information...”

10 “...Up to one-third of inflammatory bowel disease (IBD) patients can experience that biologics become...”

11 Subjects: “...Biological Products / therapeutic use...”

12 Subjects: “...Biological Products / therapeutic use...”

13 “...Given the theorized benefits of a top-down approach (early use of biologics), there is growing...”

14 “...Given the theorized benefits of a top-down approach (early use of biologics), there is growing...”

15 “... of the TST for patients with compromised immunity prior to initiating biologic treatment. Additionally...”

16 Subjects: “...Biological Assay / methods...”

17 Subjects: “...Biological Assay / methods...”

18

19 “... with immunomodulators or corticosteroids -- but never failed treatment with a biologic -- or have failed or were...”

20 “... (RA) who have had an inadequate response or intolerance to one or more biologic or non-biologic...”