1

2

3 “... of induction therapy, while the clinical criteria for the plaque psoriasis indication were: greater than 10...”

4 “... with moderately to severely active ulcerative colitis who have failed or were intolerant to treatment...”

5 “... to severely active ulcerative colitis who have had an inadequate response to, loss of response to, or were...”

6 “... who have had an inadequate response or loss of response to, or who were intolerant to either...”

7 “... who have had an inadequate response or loss of response to, or who were intolerant to either...”

8 “...Since the original CADTH reports were published, interest has emerged in the combined use...”

9 “...Since the original CADTH reports were published, interest has emerged in the combined use...”

10 “...Since the original CADTH reports were published, interest has emerged in the combined use...”

11 “...Since the original CADTH reports were published, interest has emerged in the combined use...”

12 “...Health-state utilities were further adjusted by treatment-specific time-dependent utilities based...”

13 “..., were unsuccessfully resuscitated, or critically ill patients who experienced unexpected cardiac arrest...”

14 “...Health-state utilities were further adjusted by treatment-specific time-dependent utilities based...”

15 “.... In addition, three concomitant events were incorporated to capture complications related to VTE: chronic...”

16 “.... In addition, three concomitant events were incorporated to capture complications related to VTE: chronic...”

17 “... for first-line treatment and short- and long-term AEs were assumed to occur over the first two-month cycle...”

18

19

20 “... of the SMN2 gene who were pre-symptomatic at baseline, but limitations within the clinical data informing...”