1 “... English-language studies using a peer-reviewed search strategy. The following databases were searched...”

2 “... English-language studies using a peer-reviewed search strategy. The following databases were searched...”

3

4 “... (56 trials). The most commonly studied agents were estrogens, isoflavones, and selective serotonin...”

5 “... (56 trials). The most commonly studied agents were estrogens, isoflavones, and selective serotonin...”

6

7

8

9

10 “... of this update were consistent with the 2006 review. ESAs reduced the need for transfusions and increased...”

11 “... of this update were consistent with the 2006 review. ESAs reduced the need for transfusions and increased...”

12 “... were searched from January 1, 1990, to December 16, 2011; the MEDLINE, Embase, and Cochrane searches...”

13 “... were extracted by one reviewer and audited by a second. Analyses were matched by comparing within study...”

14 “... were extracted by one reviewer and audited by a second. Analyses were matched by comparing within study...”

15 “... were searched from January 1990 to March 2012. A search of the gray literature included databases...”

16 “... were searched from January 1990 to March 2012. A search of the gray literature included databases...”

17 “... in drawing conclusions from the evidence. There were a number of important evidence gaps identified...”

18 “... in drawing conclusions from the evidence. There were a number of important evidence gaps identified...”

19 “... adverse events related to the different interventions. Data were dually abstracted by a team of four...”

20 “... adverse events related to the different interventions. Data were dually abstracted by a team of four...”