1 Subjects: “...Randomized Controlled Trials as Topic...”

2 “.... Evidence was generally consistent in direction of effect but with variable precision across studies...”

3 Subjects: “...Randomized Controlled Trials as Topic...”

4 “...; determining the cost-effectiveness of programs; and determining the effect of policy and practice...”

5 “...; determining the cost-effectiveness of programs; and determining the effect of policy and practice...”

6 “... of bias of relevant studies; they graded the strength of evidence using established criteria. We conducted...”

7 “... of bias of relevant studies; they graded the strength of evidence using established criteria. We conducted...”

8 “...LIMITATIONS: As in the earlier review, we did not find any well-conducted trials that could address...”

9 “...LIMITATIONS: As in the earlier review, we did not find any well-conducted trials that could address...”

10 “... controlled trials (RCTs) and observational studies, and (2) developing an overall SOE grade, given the scores...”

11 “...Eligible studies included randomized controlled trials (RCTs), nonrandomized trials, and cohort...”

12 “...Eligible studies included randomized controlled trials (RCTs), nonrandomized trials, and cohort...”