1 “... searched for gray literature in databases with regulatory information, clinical trial registries, abstracts...”

2 “... searched for gray literature in databases with regulatory information, clinical trial registries, abstracts...”

3 “... SOURCES: A medical librarian searched MEDLINE(r), Embase(r), and the Cochrane Controlled Trials Registry...”

4 “... SOURCES: A medical librarian searched MEDLINE(r), Embase(r), and the Cochrane Controlled Trials Registry...”

5

6

7 “...) is not supported by high-quality trial data. In the absence of these data, the comparative effectiveness and harms...”

8 “...) is not supported by high-quality trial data. In the absence of these data, the comparative effectiveness and harms...”