1 “...The time required to translate each study was tracked. The original language versions...”

2 Subjects: “...Clinical Trials as Topic...”

3 “...) in the presence of moderate to substantial between study heterogeneity, despite using random effects models...”

4 Subjects: “...Clinical Trials as Topic...”

5 Subjects: “...Randomized Controlled Trials as Topic...”

6 Subjects: “...Randomized Controlled Trials as Topic...”

7

8

9 “...), and ClinicalTrials.gov from 1990 through June 1, 2020. We included existing systematic reviews (SRs) of computed...”

10 “...), and ClinicalTrials.gov from 1990 through June 1, 2020. We included existing systematic reviews (SRs) of computed...”

11 “... studies does not suggest any worrisome adverse events beyond mild gastrointestinal intolerance...”

12 “... studies does not suggest any worrisome adverse events beyond mild gastrointestinal intolerance...”

13 “...For comparative studies, the comparator of interest was either no testing or ad hoc testing done...”

14 “...For comparative studies, the comparator of interest was either no testing or ad hoc testing done...”

15

16

17 “... elaborated upon to include possible study designs to address the topics. FUTURE RESEARCH NEEDS TOPICS...”

18 “... elaborated upon to include possible study designs to address the topics. FUTURE RESEARCH NEEDS TOPICS...”

19 “...(r), the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews from...”

20 “...(r), the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews from...”