Early biologic treatment versus conventional treatment for the management of Crohn's disease a review of comparative clinical effectiveness and cost-effectiveness

Given the theorized benefits of a top-down approach (early use of biologics), there is growing interest in its clinical effectiveness, safety, and cost-effectiveness compared to a conventional treatment approach, both in children and adults. As such, this report sought to summarize the evidence rega...

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Bibliographic Details
Main Authors: Thompson, Wade, Argáez, Charlene (Author)
Corporate Authors: Canadian Agency for Drugs and Technologies in Health, Canadian Agency for Drugs and Technologies in Health Rapid Response Service
Format: eBook
Language:English
Published: Ottawa CADTH February 13, 2019, 2019
Edition:Version 1.0
Series:CADTH rapid response report: peer-reviewed summary with critical appraisal
Subjects:
Online Access:
Collection: National Center for Biotechnology Information - Collection details see MPG.ReNa
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653 |a Early Medical Intervention 
653 |a Tumor Necrosis Factor Inhibitors / therapeutic use 
653 |a Treatment Outcome 
653 |a Adrenal Cortex Hormones / therapeutic use 
653 |a Crohn Disease / drug therapy 
653 |a Immunomodulation 
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520 |a Given the theorized benefits of a top-down approach (early use of biologics), there is growing interest in its clinical effectiveness, safety, and cost-effectiveness compared to a conventional treatment approach, both in children and adults. As such, this report sought to summarize the evidence regarding the clinical and cost-effectiveness of early biologic therapy compared to conventional treatment for Crohn's disease in children and adults. This is an upgrade of a previous CADTH rapid response titled "Early Treatment versus Conventional Treatment for the Management of Luminal Crohn's Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness"