Applications of Monte Carlo simulation in modelling of biochemical processes
"The biochemical models describing complex and dynamic metabolic systems are typically multi-parametric and non-linear, thus the identification of their parameters requires non-linear regression analysis of the experimental data. The stochastic nature of the experimental samples poses the neces...
| Main Authors: | , , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Rijeka (HR)
InTech
2011, 2011
|
| Subjects: | |
| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | "The biochemical models describing complex and dynamic metabolic systems are typically multi-parametric and non-linear, thus the identification of their parameters requires non-linear regression analysis of the experimental data. The stochastic nature of the experimental samples poses the necessity to estimate not only the values fitting best to the model, but also the distribution of the parameters, and to test statistical hypotheses about the values of these parameters. In such situations the application of analytical models for parameter distributions is totally inappropriate because their assumptions are not applicable for intrinsically non-linear regressions. That is why, Monte Carlo simulations are a powerful tool to model biochemical processes"--Introduction |
|---|---|
| Item Description: | Chapter 4 of the book: Applications of Monte Carlo methods in biology, medicine and other fields of science / Charles J Mode, editor |
| Physical Description: | 1 PDF file (pages-58-76) illustrations |