Varicocele and Male Infertility A Complete Guide

This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medi...

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Bibliographic Details
Other Authors: Esteves, Sandro C. (Editor), Cho, Chak-Lam (Editor), Majzoub, Ahmad (Editor), Agarwal, Ashok (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2019, 2019
Edition:1st ed. 2019
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Management of pediatric and adolescent varicocele
  • Part IV: Controversies with Varicocele
  • Is varicocele a bilateral disease?- Why is subclinical varicocele considered a different entity?- Why is it that not all men with varicocele are infertile?- Is there a role for testicular biopsy in men with varicocele?- Should bilateral varicocele repair be recommended in cases of a clinical varicocele and contralateral subclinical varicocele?- Is there any role for intraoperative ultrasound during varicocele repair?- Is there any role for indocyanine green angiography in testicular artery preservation during microsurgical subinguinal varicocelectomy?- Should a varicocele be repaired before assisted reproductive technology treatment?- Should a varicocele be repaired in non-infertile patients with hypogonadism?- What should be the ideal control group in clinical trials investigating the role of varicocele and its treatment on fertility outcomes?- Part V: Debate (Pro and Con) over Varicocele
  • Should SDF testing be used in men with varicocele?- Should varicocele be repaired before ART?- Should varicocele be repaired in azoospermic infertile men?- Should varicocele be managed surgically or radiographically?- Part VI: Clinical Case Scenarios Involving Varicocele
  • Grade 1 varicocele and borderline/normal conventional semen analysis
  • Grades 2/3 varicocele and normal conventional semen analysis
  • Clinical varicocele and severely abnormal semen analysis in a couple considering ART whose female partner is over 36 years old
  • Asymptomatic male with left grade 3 varicocele and 2 children desiring vasectomy with low testosterone
  • Symptomatic male with subclinical varicocele found on ultrasound evaluation
  • Recurrent grade 2/3 varicocele after microsurgical varicocelectomy and abnormal semen parameters in a couple attempting conception for >3 years
  • Part I: Varicocele Origin and Pathology
  • Anatomic theories of varicocele origin
  • Scrotal hyperthermia, hormonal disturbances, testicular hypoperfusion, and backflow of toxic metabolites in varicocele
  • Genetics and epigenetics of varicocele pathophysiology
  • Oxidative stress and varicocele pathophysiology
  • Proteomic and metabolomic profile of semen and seminal plasma in varicocele
  • Experimental varicocele
  • Part II: Clinical Evaluation of Varicocele
  • Epidemiology of varicocele in pediatric, adolescent and adult populations
  • Association between varicocele and infertility
  • Varicocele clinical diagnosis and grading
  • Imaging and other diagnostic modalities in varicocele diagnosis
  • Conventional semen analysis and specialized sperm function tests in patients with varicocele
  • Endocrine testing and the association between varicocele and hypogonadism
  • Varicocele and orchialgia
  • Part III: Therapy of Varicocele
  • Grade 2/3 varicocele in a 15-year-old healthy boy with normal testis volume (and normal semen analysis) with a history of varicocele and infertility in his father
  • Part VII: Clinical Practice Guidelines for Varicocele
  • Adult varicocele diagnosis and treatment
  • Pediatric and adolescent varicocele diagnosis and treatment
  • Sperm DNA fragmentation testing and varicocele
  • Grade of evidence on varicocele treatment
  • A ‘Strengths-Weakness-Opportunities-Threats’ (SWOT) analysis of varicocele-related infertility and its diagnosis and management
  • The evolution and refinement of varicocele treatment: A historical perspective
  • Medical therapy in varicocele-related infertility
  • Macroscopic surgical techniques for varicocele repair
  • Microscopic surgical techniques for varicocele repair
  • Laparoscopic techniques for varicocele repair
  • Interventional radiology for varicocele treatment
  • Robotic assisted microsurgical varicocelectomy
  • Effect of varicocele treatment on conventional semen analysis
  • Effect of varicocele treatment on oxidative stress markers and sperm DNA fragmentation
  • Effect of varicocele treatment on natural pregnancy outcome
  • Effect of varicocele treatment on assisted reproductive technology (ART) pregnancy outcome
  • Varicocele and azoospermia
  • Prognostic factors for a favorable outcome after varicocele repair in adults with infertility
  • Management of recurrent varicocele
  • Cost-effectiveness analysis of varicocele repair and assisted reproductive technology