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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N N and C N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the huma...

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Bibliographic Details
Main Author: Ferraz de Paiva, Raphael Enoque
Format: eBook
Language:English
Published: Cham Springer International Publishing 2018, 2018
Edition:1st ed. 2018
Series:Springer Theses, Recognizing Outstanding Ph.D. Research
Subjects:
Protein-ligand Interactions
Bioorganic Chemistry
Inorganic Chemistry
Immunology
Mass Spectrometry
Organometallic Chemistry 
Organometallic Chemistry
Proteins 
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Description
Summary:This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N N and C N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling
Physical Description:XXXIX, 151 p. 100 illus., 38 illus. in color online resource
ISBN:9783030008536

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