1 Subjects: “...Data Interpretation, Statistical...”

2 “... in populations, settings, and outcomes, and substantial statistical heterogeneity. Statistical heterogeneity...”

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4 “... resulted in a slight increase in the C statistic compared with traditional risk factor assessment alone...”

5 “... resulted in a slight increase in the C statistic compared with traditional risk factor assessment alone...”

6 “..., and estimates were imprecise. Limitations included restriction to English-language articles, statistical...”

7 “..., and estimates were imprecise. Limitations included restriction to English-language articles, statistical...”

8 “... statistically significant effects were on mean improvement in pain at immediate-term followup (weighted mean...”

9 “... statistically significant effects were on mean improvement in pain at immediate-term followup (weighted mean...”

10 “...% CI, 0.91 to 1.20]), though statistical heterogeneity was present (I2=52%), and one trial found...”

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