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240301 ||| eng |
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|a 9783031424229
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| 100 |
1 |
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|a Kinghorn, A. Douglas
|e [editor]
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| 245 |
0 |
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|a Neurotrophic Natural Products
|h Elektronische Ressource
|c edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch
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| 250 |
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|a 1st ed. 2024
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| 260 |
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|a Cham
|b Springer Nature Switzerland
|c 2024, 2024
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| 300 |
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|a IX, 473 p. 297 illus., 54 illus. in color
|b online resource
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| 505 |
0 |
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|a 1. Neurotrophins and Screening Models to Search for Neurotrophic Natural Products -- 2. Fatty Acid-Related Compounds with Neurotrophic Activity -- 3. Terpenes Possessing Neurotrophic Activity -- 4. Aromatic Compounds Possessing Neurotrophic Activity -- 5. Alkaloids Possessing Neurotrophic Properties -- 6. Closing Remarks
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| 653 |
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|a Chemical Synthesis
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| 653 |
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|a Natural products
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| 653 |
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|a Chemistry
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| 653 |
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|a Chemistry, Organic
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| 653 |
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|a Natural Products
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| 653 |
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|a Neurochemistry
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| 653 |
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|a Organic Chemistry
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| 700 |
1 |
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|a Falk, Heinz
|e [editor]
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| 700 |
1 |
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|a Gibbons, Simon
|e [editor]
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| 700 |
1 |
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|a Asakawa, Yoshinori
|e [editor]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 490 |
0 |
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|a Progress in the Chemistry of Organic Natural Products
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| 028 |
5 |
0 |
|a 10.1007/978-3-031-42422-9
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-3-031-42422-9?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 547
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| 520 |
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|a This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products
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