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|a NTP technical report on the toxicology studies of bromodichloroacetic acid (CASRN 71133-14-7) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in f344/NTac rats and B6C3F1/N mice (Drinking water studies)
|h Elektronische Ressource
|c National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services
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|a Research Triangle Park, North Carolina, USA
|b National Toxicology Program
|c October 2015, 2015
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|a 1 PDF file (various pages)
|b illustrations
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|a Includes bibliographical references
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|a National Toxicology Program (U.S.)
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|a eng
|2 ISO 639-2
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|b NCBI
|a National Center for Biotechnology Information
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|a Technical report
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|u https://www.ncbi.nlm.nih.gov/books/NBK558854
|3 Volltext
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|a 363
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|a TWO-WEEK STUDY IN F344/N RATS: Groups of five male and five female rats were exposed to 0, 62.5, 125, 250, 500, or 1,000\smg bromodichloroacetic acid/L drinking water for 16\sdays (equivalent to average daily doses of approximately 7, 15, 31, 56, or 131\smg bromodichloroacetic acid/kg body weight to males and 8, 15, 30, 58, or 113\smg/kg to females). All rats survived to the end of the study. Mean body weights of exposed groups of male and female rats were similar to those of the controls. Water consumption by exposed and control groups was similar. No organ weight differences were attributed to exposure to bromodichloroacetic acid. No gross or histologic lesions related to bromodichloroacetic acid exposure were observed.
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|a CONCLUSIONS: Under the conditions of these 2-year studies, there was clear evidence of carcinogenic activity (see Explanation of Levels of Evidence of Carcinogenic Activity; see summary of the peer review panel comments and the public discussion on this Technical Report in Appendix P) of bromodichloroacetic acid in male F344/NTac rats based on increased incidences of malignant mesothelioma and the combined incidences of epithelial tumors of the skin. Occurrences of subcutaneous fibromas were also related to exposure to bromodichloroacetic acid. Occurrences of glioma or oligodendroglioma (combined) of the brain, squamous cell papilloma and squamous cell carcinoma of the oral cavity (oral mucosa or tongue), adenoma of the large intestine, and fibroadenoma of the mammary gland may have been related to exposure to bromodichloroacetic acid.
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|a There was clear evidence of carcinogenic activity of bromodichloroacetic acid in female F344/NTac rats based on increased incidences of fibroadenoma and carcinoma of the mammary gland. The occurrences of glioma or oligodendroglioma (combined) of the brain may have been related to bromodichloroacetic acid exposure. There was clear evidence of carcinogenic activity of bromodichloroacetic acid in male B6C3F1/N mice based on increased incidences of hepatocellular carcinoma and hepatoblastoma and increased incidences of adenoma or carcinoma (combined) of the Harderian gland. There was clear evidence of carcinogenic activity of bromodichloroacetic acid in female B6C3F1/N mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma.
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|a Exposure to bromodichloroacetic acid for 2\syears resulted in increased incidences of nonneoplastic lesions in the bone marrow and liver of male and female rats, spleen of female rats, liver of male and female mice, and testis and epididymis of male mice. Synonyms: 2-Bromo-2,2-dichloroacetic acid; bromodichloroethanoic acid
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