Clear Cell Renal Cell Carcinoma 2021-2022

Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this...

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Bibliographic Details
Main Author: Manini, Claudia
Other Authors: López, José I.
Format: eBook
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
N/a
Pd1
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
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245 0 0 |a Clear Cell Renal Cell Carcinoma 2021-2022  |h Elektronische Ressource 
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300 |a 1 electronic resource (342 p.) 
653 |a machine learning 
653 |a prediction model 
653 |a pathway analysis 
653 |a radiomics 
653 |a sunitinib 
653 |a resistance 
653 |a transcriptome 
653 |a nivolumab 
653 |a responsiveness 
653 |a T-cells 
653 |a prognostic factor 
653 |a angiogenesis 
653 |a hypoxia 
653 |a renal cancer 
653 |a inter-tumoral heterogeneity 
653 |a architectural patterns 
653 |a n/a 
653 |a tumor microenvironment 
653 |a translational 
653 |a tissue slice culture 
653 |a diagnosis 
653 |a first-line treatment 
653 |a disease progression 
653 |a PD1 
653 |a magnetic resonance 
653 |a tyrosine kinase inhibitors 
653 |a clear cell kidney cancer 
653 |a prognostic factors 
653 |a epigenetics 
653 |a metastatic clear cell renal cell carcinoma 
653 |a combinations 
653 |a clear-cell renal cell carcinoma 
653 |a imaging 
653 |a plasma 
653 |a thyroid 
653 |a intra-tumoral heterogeneity 
653 |a immunotherapy 
653 |a molecular features 
653 |a inter-metastatic heterogeneity 
653 |a immune related adverse events (irAEs) 
653 |a PBRM1 
653 |a single-cell RNA sequencing 
653 |a ddPCR 
653 |a PD-L1 
653 |a cancer immunotherapy 
653 |a treatment resistance 
653 |a renal cell cancer 
653 |a adjuvant therapy 
653 |a clear cell renal cell carcinoma 
653 |a intratumor heterogeneity 
653 |a DNA methylation 
653 |a circulating miRNA 
653 |a biomarkers 
653 |a immune landscape 
653 |a cystic tumor 
653 |a oleic acid 
653 |a immune checkpoint inhibitors 
653 |a prognosis 
653 |a multisite tumor sampling 
653 |a biomarker 
653 |a kidney 
653 |a immune checkpoint inhibitor 
653 |a SCD-1 
653 |a renal cell carcinoma 
653 |a malignancy 
653 |a PD-1 
653 |a surgery 
653 |a RNA sequencing 
653 |a miRNA 
653 |a endothelial cells 
653 |a gene expression 
653 |a Clinical and internal medicine / bicssc 
653 |a Medicine and Nursing / bicssc 
653 |a immunohistochemistry 
653 |a cutaneous 
653 |a histomorphological features 
653 |a radiogenomics 
700 1 |a López, José I. 
700 1 |a Manini, Claudia 
700 1 |a López, José I. 
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520 |a Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this tumor make it an exciting meeting point for translational collaboration between clinicians and basic researchers. Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. This tumor is also a good example to investigate the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. A deeper identification of the varied internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizers, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Clear cell renal cell carcinoma is also a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway.