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Marine Compounds and Cancer 2020

The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the las...

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Bibliographic Details
Main Author:	Honecker, Friedemann
Other Authors:	Dyshlovoy, Sergey A.
Format:	eBook
Language:	English
Published:	Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:	Antioxidant Lampetra Morii Multidrug Resistance Bromophenol Apoptosis-inducing Activity Cell Adhesion Molecules Abc Transporter P38α Brevianamide Nur77 Humulane Sesquiterpenoids Ad0157 P38/erk Nf-κb Signaling Plakortide Marine-derived Drugs Fucoidan Tumor Microenvironment Trabectedin Non-small Cell Lung Carcinoma Fau Antiproliferative Activity Membrane Permeabilization Fucoxanthin Angiogenesis Inhibitor Tumor Cell Line Mitochondria Kalkitoxin Sponges Pel Antitumour Human Sarcoma Cell Line (ht1080 Cells) Pi3k/akt Cytoskeleton Penicillium Brevicompactum Endoperoxide Non-small Cell Lung Cancer Marine Antitumor Agents Cembranoids Polyoxygenated Steroids Sipholenol A Jaspine B Anthranilic Acid Prostate Cancer Sz-685c Fbdd A375 And Hela Cell Lines Synergism Bel-7402 Cell Gliotoxin Natural Marine Compounds Hydroxylated Lipids Brominated Indoles Nf-κb Seaweed Phycocyanin Arrest Of Cell Cycle Cancer Anticarcinogenic Epigonal Organ Caspase Cascade Lung Cancer Antiangiogenic Programmed Cell Death-ligand 2 Cancer Genes Lyngbya Majuscula Mrp1/abcc1 Xyloketal B Antiangiogenesis Penicillium Paneum Cyclin D1 Et-743 Chromatography Chemotherapy Anti-metastatic Activity Sediment Invasion Novel Inhibitor Cytotoxicity Proteomic Proliferation Pyrrolidinedione Tgf-β Signaling Nsclc Circulating Tumor Cells Moorea Producens Bioactive Natural Product Antiproliferative Hif-1 Cytotoxic Activity Microalgae Mitochondria Toxin Ansamycins Marine Natural Products Cystatin F Porifera C-jun N/a Gemcitabine λ-carrageenan Natural Products Anti-cancer 3-alkylpyridinium Polymers 12-deacetyl-12-epi-scalaradial Fascaplysin Cell Adhesion Inhibitor Autophagy Inhibitors Neuroblastoma-rat Sarcoma Ros Energy Stress Antifouling Glioblastoma Molecular Docking Streptomyces Sp. Scsio 11594 Cell Cycle Arrest Poly(adp-ribose)-polymerase Inhibitor Benzo[a]pyrene Pachastrissamine Carotenoid Stat3 Ap-1 Topoisomerase Chemoprevention Pheochromocytoma And Paraganglioma Mechanisms Of Action Polysaccharides Selenium-containing Polysaccharide-protein Complex Cyp1a1 Dna Minor Groove Binder αo-conotoxin Gexiva Snora62 Chemosensitization C-met Marine Sponges Anticancer Immunity β1-integrin Emt Topo I Inhibitor Drug Discovery Leukemia Marine Drug Antibacterial Phlorotannins P38 Antitumor Activities Puupehenones Cancer Progression Fumigaclavine C Fatty Acid 2-hydroxylase Manzamine A Chop Gene Expression Marine Organisms Breast Cancer Cells Sea Anemone Anti-proliferation Heparanase Marine Mollusc Leathesia Nana Soft Tissue Sarcoma Divergolides P65 Cantabrian Sea-derived Actinobacteria Itampolin A Soft Coral Ecklonia Cava Programmed Cell Death Hypoxia Marthasterias Glacialis L. Hepatocellular Carcinoma Cancer Preventive Autophagy Inducers Mitochondrial Pathway Epithelial-mesenchymal Transition Kunitz Type Inhibitor Glycosaminoglycans Safety Non-small Cell Lung Cancer (nsclc) Marine Metabolites Tnfα Dibromotyrosine Carotenoids Cyclin-dependent Kinase Cisplatin Nicotinic Acetylcholine Receptor Sepia Ink Polysaccharides Pollution Mapk/erk Pathway Her2 Small Cell Lung Cancer Mcp-1 Haliclona Gracilis Anti-angiogenic Thalassiolin B Clinical Trials Bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (bddpm) Isofistularin Gorgonian Antitumor Molecular Oncology Human Lung Cancer Elisidepsin P2x7 Receptor Akt Rgd Motif Lung Metastasis Uveal Melanoma Secondary Metabolites Bioanalysis Azoxymethane Reactive Oxygen Species Colorectal Cancer Nanoparticle Chemical Conjugation Naphthopyrones Human Normal Diploid Fibroblast (tig-1 Cells) Sphingosine Kinase Inhibitor Trpm7 Depolymerisation Multi-drug Resistant Leukemia Heparan Sulphate Therapeutic Compounds Carcinoembryonic Antigen Anti-proliferative Antibody Drug Conjugates (adcs) Araguspongine C Triterpene Glycosides Melanoma Integrin β1 Ls-1 Low Molecular Weight Fucoidan Extract Molecular Mechanisms Autophagy Migration Anticancer Agent Mycalin A Micromonospora Evolution Molecular Modeling Tilapia Piscidin 4 (tp4) Hela Cells Sea Cucumbers Natural Product Targeted Therapy Medicine And Nursing / Bicssc Aspergillus Bcrp/abcg2 Cytokine Release C15 Acetogenins Polyphenols Fak Mitochondrial Dysfunction Sinulariolide Anti-angiogenesis Pazopanib Terpenes Marangucyclines Thalassia Testudinum α9-nicotinic Acetylcholine Receptors (nachrs) Angiogenesis Cell Cycle Dieckol Inflammation Sarcophyton Ehrenbergi Vegf Tetracenomycin X Actinomycin Chimera Glucocorticoid Receptor Synthetic Analogues Fatty Acids Carbocyclic Analogue Hsp90 Mycochromenic Acid Derivative Deep-sea Cell Migration N-ras Nicotine Preclinical Hypoxia-inducible Factor-1 Anticoagulation Jurkat Shrimp Pseudopterosin A549 Cells Caribbean Sponge Anticancer Jnk1/2 Antitumoral Mangrove-derived Actinomycete Marine Fungus Anticoagulant Ribosomal Protein Genes Macrolide Marine Biotechnology Anticancer Activity Apoptosis Approved Antitumor Agents Hippuristanol Nonfunctioning Pituitary Adenomas Breast Cancer Proteasomal Degradation Camptothecin Sponge Endophytic Fungus Virtual Screening Palmitic Acid Aeroplysinin Cystatin Superfamily Rps30 Porifera/sponge Snorna Paulomycins Cooperative Binding Metastasis Ulva Fasciata Programmed Cell Death-ligand 1 Tumor-associated Macrophages Lipid Rafts Marine Drugs Oxidative Stress Il-6 Antimicrobial Peptide (amp) Low Toxic Isatin Leptogorgia Bonnethead Shark Osteosarcoma Endothelial Cells Hybridization P-gp/abcb1 Er-stress In Vivo Model Snu-c5/5-fu Phase I Signal Transduction Plitidepsin Adriamycin Resistance Marine Compound Chemopreventive Buccal Gland
Online Access:	https://www.mdpi.com/books/pdfview/book/3853 https://directory.doabooks.org/handle/20.500.12854...
Collection:	Directory of Open Access Books - Collection details see MPG.ReNa


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020			\|a 9783036506319
020			\|a books978-3-0365-0631-9
020			\|a 9783036506302
100	1		\|a Honecker, Friedemann
245	0	0	\|a Marine Compounds and Cancer 2020 \|h Elektronische Ressource
260			\|a Basel, Switzerland \|b MDPI - Multidisciplinary Digital Publishing Institute \|c 2021
300			\|a 1 electronic resource (480 p.)
653			\|a antioxidant
653			\|a Lampetra morii
653			\|a multidrug resistance
653			\|a bromophenol
653			\|a apoptosis-inducing activity
653			\|a cell adhesion molecules
653			\|a ABC transporter
653			\|a p38α
653			\|a Brevianamide
653			\|a Nur77
653			\|a humulane sesquiterpenoids
653			\|a AD0157
653			\|a p38/ERK
653			\|a NF-κB signaling
653			\|a plakortide
653			\|a marine-derived drugs
653			\|a fucoidan
653			\|a tumor microenvironment
653			\|a trabectedin
653			\|a non-small cell lung carcinoma
653			\|a FAU
653			\|a antiproliferative activity
653			\|a membrane permeabilization
653			\|a fucoxanthin
653			\|a angiogenesis inhibitor
653			\|a tumor cell line
653			\|a mitochondria
653			\|a kalkitoxin
653			\|a sponges
653			\|a PEL
653			\|a antitumour
653			\|a human sarcoma cell line (HT1080 cells)
653			\|a PI3K/Akt
653			\|a cytoskeleton
653			\|a Penicillium brevicompactum
653			\|a endoperoxide
653			\|a non-small cell lung cancer
653			\|a marine antitumor agents
653			\|a cembranoids
653			\|a polyoxygenated steroids
653			\|a sipholenol A
653			\|a jaspine B
653			\|a anthranilic acid
653			\|a prostate cancer
653			\|a SZ-685C
653			\|a FBDD
653			\|a A375 and HeLa cell lines
653			\|a synergism
653			\|a BEL-7402 cell
653			\|a gliotoxin
653			\|a natural marine compounds
653			\|a hydroxylated lipids
653			\|a brominated indoles
653			\|a NF-κB
653			\|a seaweed
653			\|a phycocyanin
653			\|a arrest of cell cycle
653			\|a cancer
653			\|a anticarcinogenic
653			\|a epigonal organ
653			\|a caspase cascade
653			\|a lung cancer
653			\|a antiangiogenic
653			\|a programmed cell death-ligand 2
653			\|a cancer genes
653			\|a Lyngbya majuscula
653			\|a MRP1/ABCC1
653			\|a xyloketal B
653			\|a antiangiogenesis
653			\|a Penicillium paneum
653			\|a cyclin D1
653			\|a ET-743
653			\|a chromatography
653			\|a chemotherapy
653			\|a anti-metastatic activity
653			\|a sediment
653			\|a invasion
653			\|a novel inhibitor
653			\|a cytotoxicity
653			\|a proteomic
653			\|a proliferation
653			\|a pyrrolidinedione
653			\|a TGF-β signaling
653			\|a NSCLC
653			\|a circulating tumor cells
653			\|a Moorea producens
653			\|a bioactive natural product
653			\|a antiproliferative
653			\|a HIF-1
653			\|a cytotoxic activity
653			\|a microalgae
653			\|a mitochondria toxin
653			\|a ansamycins
653			\|a marine natural products
653			\|a cystatin F
653			\|a Porifera
653			\|a c-JUN
653			\|a n/a
653			\|a gemcitabine
653			\|a λ-carrageenan
653			\|a natural products
653			\|a anti-cancer
653			\|a 3-alkylpyridinium polymers
653			\|a 12-deacetyl-12-epi-scalaradial
653			\|a fascaplysin
653			\|a cell adhesion
653			\|a inhibitor
653			\|a autophagy inhibitors
653			\|a neuroblastoma-rat sarcoma
653			\|a ROS
653			\|a energy stress
653			\|a antifouling
653			\|a glioblastoma
653			\|a molecular docking
653			\|a Streptomyces sp. SCSIO 11594
653			\|a cell cycle arrest
653			\|a poly(ADP-ribose)-polymerase inhibitor
653			\|a benzo[a]pyrene
653			\|a pachastrissamine
653			\|a carotenoid
653			\|a STAT3
653			\|a AP-1
653			\|a topoisomerase
653			\|a chemoprevention
653			\|a pheochromocytoma and paraganglioma
653			\|a mechanisms of action
653			\|a polysaccharides
653			\|a selenium-containing polysaccharide-protein complex
653			\|a CYP1A1
653			\|a DNA minor groove binder
653			\|a αO-conotoxin GeXIVA
653			\|a SNORA62
653			\|a chemosensitization
653			\|a c-Met
653			\|a marine sponges
653			\|a anticancer immunity
653			\|a β1-integrin
653			\|a EMT
653			\|a Topo I inhibitor
653			\|a drug discovery
653			\|a leukemia
653			\|a marine drug
653			\|a antibacterial
653			\|a phlorotannins
653			\|a p38
653			\|a antitumor activities
653			\|a puupehenones
653			\|a cancer progression
653			\|a fumigaclavine C
653			\|a fatty acid 2-hydroxylase
653			\|a manzamine A
653			\|a CHOP
653			\|a gene expression
653			\|a marine organisms
653			\|a breast cancer cells
653			\|a sea anemone
653			\|a anti-proliferation
653			\|a heparanase
653			\|a marine mollusc
653			\|a Leathesia nana
653			\|a soft tissue sarcoma
653			\|a divergolides
653			\|a p65
653			\|a Cantabrian Sea-derived actinobacteria
653			\|a itampolin A
653			\|a soft coral
653			\|a Ecklonia cava
653			\|a programmed cell death
653			\|a hypoxia
653			\|a Marthasterias glacialis L.
653			\|a hepatocellular carcinoma
653			\|a cancer preventive
653			\|a autophagy inducers
653			\|a mitochondrial pathway
653			\|a epithelial-mesenchymal transition
653			\|a kunitz type inhibitor
653			\|a glycosaminoglycans
653			\|a safety
653			\|a non-small cell lung cancer (NSCLC)
653			\|a marine metabolites
653			\|a TNFα
653			\|a dibromotyrosine
653			\|a carotenoids
653			\|a cyclin-dependent kinase
653			\|a cisplatin
653			\|a nicotinic acetylcholine receptor
653			\|a Sepia ink polysaccharides
653			\|a pollution
653			\|a MAPK/ERK pathway
653			\|a HER2
653			\|a small cell lung cancer
653			\|a MCP-1
653			\|a Haliclona gracilis
653			\|a anti-angiogenic
653			\|a thalassiolin B
653			\|a clinical trials
653			\|a bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM)
653			\|a Isofistularin
653			\|a gorgonian
653			\|a antitumor
653			\|a molecular oncology
653			\|a human lung cancer
653			\|a elisidepsin
653			\|a P2X7 receptor
653			\|a Akt
653			\|a RGD motif
653			\|a lung metastasis
653			\|a uveal melanoma
653			\|a secondary metabolites
653			\|a bioanalysis
653			\|a azoxymethane
653			\|a reactive oxygen species
653			\|a colorectal cancer
653			\|a nanoparticle
653			\|a chemical conjugation
653			\|a naphthopyrones
653			\|a human normal diploid fibroblast (TIG-1 cells)
653			\|a sphingosine kinase inhibitor
653			\|a TRPM7
653			\|a depolymerisation
653			\|a multi-drug resistant leukemia
653			\|a heparan sulphate
653			\|a therapeutic compounds
653			\|a carcinoembryonic antigen
653			\|a anti-proliferative
653			\|a Antibody Drug Conjugates (ADCs)
653			\|a araguspongine C
653			\|a triterpene glycosides
653			\|a melanoma
653			\|a integrin β1
653			\|a LS-1
653			\|a low molecular weight fucoidan extract
653			\|a molecular mechanisms
653			\|a autophagy
653			\|a migration
653			\|a anticancer agent
653			\|a Mycalin A
653			\|a Micromonospora
653			\|a evolution
653			\|a molecular modeling
653			\|a Tilapia piscidin 4 (TP4)
653			\|a HeLa cells
653			\|a sea cucumbers
653			\|a natural product
653			\|a targeted therapy
653			\|a Medicine and Nursing / bicssc
653			\|a Aspergillus
653			\|a BCRP/ABCG2
653			\|a cytokine release
653			\|a C15 acetogenins
653			\|a polyphenols
653			\|a FAK
653			\|a mitochondrial dysfunction
653			\|a sinulariolide
653			\|a anti-angiogenesis
653			\|a pazopanib
653			\|a terpenes
653			\|a marangucyclines
653			\|a Thalassia testudinum
653			\|a α9-nicotinic acetylcholine receptors (nAChRs)
653			\|a angiogenesis
653			\|a cell cycle
653			\|a dieckol
653			\|a inflammation
653			\|a Sarcophyton ehrenbergi
653			\|a VEGF
653			\|a tetracenomycin X
653			\|a actinomycin
653			\|a Cancer
653			\|a chimera
653			\|a glucocorticoid receptor
653			\|a synthetic analogues
653			\|a fatty acids
653			\|a carbocyclic analogue
653			\|a HSP90
653			\|a Mycochromenic acid derivative
653			\|a deep-sea
653			\|a cell migration
653			\|a N-Ras
653			\|a nicotine
653			\|a preclinical
653			\|a hypoxia-inducible factor-1
653			\|a anticoagulation
653			\|a Jurkat
653			\|a shrimp
653			\|a pseudopterosin
653			\|a A549 cells
653			\|a Caribbean sponge
653			\|a anticancer
653			\|a JNK1/2
653			\|a antitumoral
653			\|a mangrove-derived actinomycete
653			\|a marine fungus
653			\|a anticoagulant
653			\|a ribosomal protein genes
653			\|a macrolide
653			\|a marine biotechnology
653			\|a anticancer activity
653			\|a apoptosis
653			\|a approved antitumor agents
653			\|a hippuristanol
653			\|a nonfunctioning pituitary adenomas
653			\|a breast cancer
653			\|a proteasomal degradation
653			\|a camptothecin
653			\|a sponge
653			\|a endophytic fungus
653			\|a virtual screening
653			\|a palmitic acid
653			\|a Aeroplysinin
653			\|a cystatin superfamily
653			\|a RPS30
653			\|a porifera/sponge
653			\|a snoRNA
653			\|a paulomycins
653			\|a cooperative binding
653			\|a metastasis
653			\|a Ulva fasciata
653			\|a programmed cell death-ligand 1
653			\|a tumor-associated macrophages
653			\|a lipid rafts
653			\|a marine drugs
653			\|a oxidative stress
653			\|a IL-6
653			\|a Antimicrobial peptide (AMP)
653			\|a low toxic
653			\|a isatin
653			\|a Leptogorgia
653			\|a bonnethead shark
653			\|a osteosarcoma
653			\|a endothelial cells
653			\|a hybridization
653			\|a P-gp/ABCB1
653			\|a ER-stress
653			\|a in vivo model
653			\|a SNU-C5/5-FU
653			\|a phase I
653			\|a signal transduction
653			\|a plitidepsin
653			\|a adriamycin resistance
653			\|a marine compound
653			\|a chemopreventive
653			\|a buccal gland
700	1		\|a Dyshlovoy, Sergey A.
700	1		\|a Honecker, Friedemann
700	1		\|a Dyshlovoy, Sergey A.
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989			\|b DOAB \|a Directory of Open Access Books
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520			\|a The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.

Marine Compounds and Cancer 2020

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