Pharmacology of the WNT Signaling System
This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of...
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Cham
Springer International Publishing
2021, 2021
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| Edition: | 1st ed. 2021 |
| Series: | Handbook of Experimental Pharmacology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Pharmacological thinking in WNT signaling
- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically
- WNTs on exosomes
- Strategies to target LRPs in WNT signaling
- Targeting the receptor tyrosine kinase ROR1 by small molecules
- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors
- Disheveled proteins as crucial mediators of WNT signaling
- Destruction complex and regulation of CTNNB1
- Strategies to therapeutically target WNT/PCP like signaling in disease
- Mining natural compounds to target WNT signaling - from mushrooms to corals
- FZD7 as a therapeutic target in intestinal cancer
- Targeting oncogenic WNT signaling with WNT derived peptides
- Targeting WNT signaling in lung pathology
- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting
- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy?
- Targeting WNT signaling as a risk