Amide Bond Activation

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N-C bond activation in electrophilic, Lewis acid, radical, and n...

Full description

Bibliographic Details
Main Author: Szostak, Michal
Format: eBook
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
Subjects:
Dmf
N
Online Access:
Collection: Directory of Open Access Books - Collection details see MPG.ReNa
LEADER 05914nma a2201885 u 4500
001 EB001970912
003 EBX01000000000000001133814
005 00000000000000.0
007 cr|||||||||||||||||||||
008 210512 ||| eng
020 |a 9783039212040 
020 |a 9783039212033 
020 |a books978-3-03921-204-0 
100 1 |a Szostak, Michal 
245 0 0 |a Amide Bond Activation  |h Elektronische Ressource 
260 |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2019 
300 |a 1 electronic resource (466 p.) 
653 |a formylation 
653 |a C-N ? bond cleavage 
653 |a cytostatic activity 
653 |a twisted amide 
653 |a pre-catalysts 
653 |a C-N bond cleavage 
653 |a nitrogen heterocycles 
653 |a rotational barrier energy 
653 |a DMF 
653 |a carbanions 
653 |a Winkler-Dunitz parameters 
653 |a fumardiamide 
653 |a additivity principle 
653 |a amides 
653 |a reaction mechanism 
653 |a density functional theory 
653 |a amide bond activation 
653 |a molecular dynamics 
653 |a [2+2+2] annulation 
653 |a bridged lactams 
653 |a amino acid transporters 
653 |a intein 
653 |a succindiamide 
653 |a N-dimethylacetamide 
653 |a amination 
653 |a heterocycles 
653 |a trialkylborane 
653 |a twisted amides 
653 |a C-H functionalization 
653 |a aminosulfonylation 
653 |a Suzuki-Miyaura 
653 |a antibacterial screening 
653 |a multi-component coupling reaction 
653 |a acyl transfer 
653 |a amidicity 
653 |a homogeneous catalysis 
653 |a ester bond activation 
653 |a palladium 
653 |a base-catalyed hydrolysis 
653 |a pharmacokinetics 
653 |a intramolecular catalysis 
653 |a pancreatic cancer cells 
653 |a Michael acceptor 
653 |a sodium 
653 |a physical organic chemistry 
653 |a DMAc 
653 |a cyclization 
653 |a aminoacylation 
653 |a distortion 
653 |a non planar amide 
653 |a tert-butyl 
653 |a enzymes 
653 |a dipeptides 
653 |a directing groups 
653 |a N-heterocyclic carbene 
653 |a transamidation 
653 |a C-H/C-N activation 
653 |a rhodium 
653 |a N 
653 |a amide bonds 
653 |a metal complexes 
653 |a catalysis 
653 |a metabolic stability 
653 |a aryl esters 
653 |a amide bond resonance 
653 |a pyramidal amides 
653 |a N-C activation 
653 |a C-H acidity 
653 |a HERON reaction 
653 |a Pd-catalysis 
653 |a steric effects 
653 |a acylative cross-coupling 
653 |a amide 
653 |a crown ether 
653 |a amine 
653 |a kinetic 
653 |a in situ 
653 |a nitro-aci tautomerism 
653 |a C-H bond cleavage 
653 |a water solvation 
653 |a protease 
653 |a biofilm eradication 
653 |a density-functional theory 
653 |a addition reaction 
653 |a amide bond 
653 |a thiourea 
653 |a secondary amides 
653 |a nickel catalysis 
653 |a C-O activation 
653 |a nuclear magnetic resonance 
653 |a excited state 
653 |a organic synthesis 
653 |a amidation 
653 |a N-heterocyclic carbenes (NHCs) 
653 |a ruthenium (Ru) 
653 |a C-S formation 
653 |a model compound 
653 |a amide resonance 
653 |a amide hydrolysis 
653 |a bridged sultams 
653 |a arynes 
653 |a catalyst 
653 |a N-dimethylformamide 
653 |a carbonylation 
653 |a cis/trans isomerization 
653 |a cyclopentadienyl complexes 
653 |a aryl thioamides 
653 |a cyanation 
653 |a insertion 
653 |a transition metals 
653 |a transition-metal-free 
653 |a synthesis 
653 |a amide activation 
653 |a thioamidation 
653 |a entropy 
653 |a amide C-N bond activation 
653 |a anomeric effect 
653 |a reaction thermodynamics 
653 |a hypersensitivity 
653 |a primaquine 
653 |a DFT study 
653 |a activation 
653 |a carbonylicity 
653 |a cross-coupling 
653 |a N-(1-naphthyl)acetamide 
653 |a palladium catalysis 
653 |a sulfonamide bond 
653 |a gemcitabine prodrug 
653 |a alkynes 
653 |a peptide bond cleavage 
653 |a Chemistry / bicssc 
653 |a antiviral activity 
653 |a catalysts 
041 0 7 |a eng  |2 ISO 639-2 
989 |b DOAB  |a Directory of Open Access Books 
500 |a Creative Commons (cc), https://creativecommons.org/licenses/by-nc-nd/4.0/ 
028 5 0 |a 10.3390/books978-3-03921-204-0 
856 4 2 |u https://directory.doabooks.org/handle/20.500.12854/40763  |z DOAB: description of the publication 
856 4 0 |u https://www.mdpi.com/books/pdfview/book/1420  |7 0  |x Verlag  |3 Volltext 
082 0 |a 540 
082 0 |a 333 
082 0 |a 380 
520 |a The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N-C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.