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200810 ||| eng |
| 020 |
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|a 9789811555305
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| 100 |
1 |
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|a Singh, Dev Bukhsh
|e [editor]
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| 245 |
0 |
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|a Frontiers in Protein Structure, Function, and Dynamics
|h Elektronische Ressource
|c edited by Dev Bukhsh Singh, Timir Tripathi
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| 250 |
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|a 1st ed. 2020
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| 260 |
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|a Singapore
|b Springer Nature Singapore
|c 2020, 2020
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| 300 |
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|a XII, 452 p. 71 illus., 54 illus. in color
|b online resource
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| 505 |
0 |
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|a Chapter 1. Protein Purification, Estimation, Storage and Effect on Structure, Function and Dynamics -- Chapter 2. Experimental and Computational Methods to Determine Protein Structure and Stability -- Chapter 3. Wet-Lab Approaches to Determine Three-Dimensional Structures of Proteins -- Chapter 4. Use of Group Specific Reagents in Active Site Functional Group Elucidation I: Cys, Ser, Tyr and Trp Residues -- Chapter 5. Use of Group Specific Reagents in Active Site Functional Group Elucidation II: Asp, Glu, Arg, Lys and His residues -- Chapter 6. Protein-Protein Interactions Modeling: From Dry to Wet Lab -- Chapter 7. Thermodynamics of Protein-Ligand Binding -- Chapter 8. SynergisticEffects of Hydration Sites in Protein Stability: A Theoretical Water Thermodynamics Approach -- Chapter 9. Molecular Dynamics Simulation: Methods and Application -- Chapter 10. Protein Folding, Dynamics and Aggregation at Single Molecule Resolution -- Chapter 11. Protein Misfolding and Neurodegenerative Diseases -- Chapter 12. Management of Insulin Through Co-Solute Engineering: A Therapeutic Approach -- Chapter 13. Structural and Functional Aspects of Muscarinic Receptors in Correlation with Anticholinergic Drugs -- Chapter 14. Dopamine Β Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases -- Chapter 15. Molecular Motors: Subdomain Dynamics and Mechanochemistry -- Chapter 16. Structural and Functional Dynamics of Lysosomal Cysteine Proteases with Particular Reference to Cathepsin B and Cathepsin H -- Chapter 17. An Insight into the Importance of Ferritins in the Physiology of Mycobacterium tuberculosis: Unique Structural and Functional Properties
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| 653 |
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|a Proteins
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| 653 |
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|a Bioinformatics
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| 653 |
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|a Medical Genetics
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| 653 |
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|a Protein Biochemistry
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| 653 |
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|a Medical genetics
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| 653 |
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|a Enzymology
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| 653 |
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|a Proteins
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| 700 |
1 |
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|a Tripathi, Timir
|e [editor]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 028 |
5 |
0 |
|a 10.1007/978-981-15-5530-5
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-981-15-5530-5?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 572.6
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| 520 |
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|a This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances. Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecularmotors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction
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