Design and Analysis of Subgroups with Biopharmaceutical Applications
This book provides an overview of the theories and applications on subgroups in the biopharmaceutical industry. Drawing from a range of expert perspectives in academia and industry, this collection offers an overarching dialogue about recent advances in biopharmaceutical applications, novel statisti...
| Other Authors: | , , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Cham
Springer International Publishing
2020, 2020
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| Edition: | 1st ed. 2020 |
| Series: | Emerging Topics in Statistics and Biostatistics
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- 1. Data-driven and Confirmatory Subgroup Analysis in Clinical Trials
- 2. Subgroup Analysis – A View from Industry
- 3. Biomarker-Targeted Confirmatory Trials
- 4. Considerations on Subgroup Analysis in Design and Analysis of Multi-Regional Clinical Trials
- 5. Practical Subgroup Identification Strategies in Late-stage Clinical Trials
- 6. Exploratory Subgroup Identification for Biopharmaceutical Development
- 7. Logical Inference on Treatment Efficacy When Subgroup Exists
- 8. The GUIDE Approach to Subgroup Identification and Inference
- 9. Use of the VG (Virtual Twins Combined with GUIDE) Method in the Development of Precision Medicines
- 10. Subgroups Identification for Tailored Therapies: a System of Methods, a Framework for Consistent Methodology Evaluation, and an Integrated Learn-and-confirm Approach
- 11. Developing and Validating Predictive Classifiers in Randomized Clinical Trials
- 12. Issues Related to Subgroup Analysis
- 13. Subgroup Analysis with Partial Linear Model
- 14. Subgroup Analysis in the 21st Century
- 15. Power of Statistical Tests for Subgroup Analysis in Meta-Analysis
- 16. Heterogeneity and Subgroup Analysis in Network Meta-Analysis