Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kma...

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Main Author: Bao, Xiucong
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Singapore Springer Singapore 2020, 2020
Edition:1st ed. 2020
Series:Springer Theses, Recognizing Outstanding Ph.D. Research
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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245 0 0 |a Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation  |h Elektronische Ressource  |c by Xiucong Bao 
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300 |a XVIII, 163 p. 132 illus., 96 illus. in color  |b online resource 
505 0 |a Introduction to Protein Posttranslational Modifications (PTMs) -- Chemical reporter for Lysine Malonylation -- Identification of Histone Lysine Glutarylation -- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly -- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach 
653 |a Protein Structure 
653 |a Posttranslational Modification 
653 |a Cell cycle 
653 |a Bioorganic Chemistry 
653 |a Posttranslational modification 
653 |a Cell Cycle Analysis 
653 |a Proteomics 
653 |a Proteomics 
653 |a Bioorganic chemistry 
653 |a Gene Expression 
653 |a Proteins  
653 |a Gene expression 
710 2 |a SpringerLink (Online service) 
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989 |b Springer  |a Springer eBooks 2005- 
490 0 |a Springer Theses, Recognizing Outstanding Ph.D. Research 
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082 0 |a 547 
520 |a This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases