| Summary: | In a letter to the regional health authorities of November 26, 2015, the Ministry of Health and Care Services stated that all patients in psychiatric care should be able to choose treatments without medication, when appropriate. Offering treatment without antipsychotics has been an expressed wish by patients suffering from psychosis, but the benefits and harms of treatment without medication for patients in active psychosis is unknown. The objective of the project was to identify and review studies on psychosocial treatment without use of antipsychotics compared to psychosocial treatment with use of antipsychotics for patient with active psychosis. Two commissions were received at the same time, and as both comprised the effect of an intervention with and without antipsychotics for the same group of patients, the search was combined. We searched for references in five electronic databases and identified almost 20,000 references for the effect of psychosocial treatment or physical activity for patients with active psychosis. After reviewing the references and possibly relevant articles, we found no studies that had evaluated the effect of psychosocial treatment without use of antipsychotics compared to psychosocial treatment where the patient with active psychosis with simultaneous use antipsychotics. The effects of treatment of persons with active psychosis without antipsychotics is therefore uncertain
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