Table of Contents:
  • The pathophysiology of vaso-occlusive crises (VOC) in sickle cell disease (SCD)
  • Vaso-occlusion is a complex process involving increased adhesion molecule expression
  • Intravascular hemolysis and the resultant scavenging of nitric oxide
  • Apply guideline based care to adults with SCD
  • Exchange transfusion can be used when a simple transfusion may lead to hyperviscosity
  • Treatment using Hydroxyurea or L-glutamine
  • Neurocognitive dysfunction as a complication of SCD.