Evidence synthesis in the baseline natural history model

This Technical Support Document reviews synthesis issues that arise on the construction of a baseline natural history model. The intention is to cover both the absolute response to treatment on the outcome measures on which comparative effectiveness is defined, and also other elements of the natural...

Full description

Main Authors: Dias, Sofia, Welton, Nicky J. (Author), Sutton, A. J. (Author), Ades, A. E. (Author)
Corporate Author: National Institute for Health and Clinical Excellence (Great Britain) Decision Support Unit
Format: eBook
Language:English
Published: London National Institute for Health and Clinical Excellence (NICE) April 2012, 2012
Edition:Updated
Series:NICE DSU technical support document
Subjects:
Online Access:
Collection: National Center for Biotechnology Information - Collection details see MPG.ReNa
Summary:This Technical Support Document reviews synthesis issues that arise on the construction of a baseline natural history model. The intention is to cover both the absolute response to treatment on the outcome measures on which comparative effectiveness is defined, and also other elements of the natural history model, which are usually "downstream" of the shorter-term effects reported in trials. The TSDs provide a review of the current state of the art in each topic area, and make clear recommendations on the implementation of methods and reporting standards where it is appropriate to do so. They aim to provide assistance to all those involved in submitting or critiquing evidence as part of NICE Technology Appraisals, whether manufacturers, assessment groups or any other stakeholder type
Physical Description:1 PDF file (29 pages) illustrations