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181201 ||| eng |
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|a 9783030007379
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| 100 |
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|a Djouder, Nabil
|e [editor]
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| 245 |
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|a Prefoldins: the new chaperones
|h Elektronische Ressource
|c edited by Nabil Djouder
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| 250 |
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|a 1st ed. 2018
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| 260 |
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|a Cham
|b Springer International Publishing
|c 2018, 2018
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| 300 |
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|a IX, 135 p. 39 illus., 36 illus. in color
|b online resource
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| 505 |
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|a Preface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index
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| 653 |
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|a Cell Biology
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| 653 |
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|a Proteins
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| 653 |
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|a Medical Genetics
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| 653 |
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|a Medicine / Research
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| 653 |
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|a Protein Biochemistry
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| 653 |
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|a Cytology
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| 653 |
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|a Biology / Research
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| 653 |
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|a Medical genetics
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| 653 |
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|a Cancer
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| 653 |
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|a Biomedical Research
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| 653 |
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|a Proteins
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| 653 |
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|a Cancer Biology
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 490 |
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|a Advances in Experimental Medicine and Biology
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| 028 |
5 |
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|a 10.1007/978-3-030-00737-9
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-030-00737-9?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
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|a 616.042
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| 520 |
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|a This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world
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