Mathematical Modeling of Protein Complexes

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducin...

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Main Authors: Koshlan, Tatiana, Kulikov, Kirill (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2018, 2018
Edition:1st ed. 2018
Series:Biological and Medical Physics, Biomedical Engineering
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Introduction
  • Physical methods for studying proteins
  • Physical properties of amino acids and proteins
  • Selection of a biological objects
  • Mathematical simulation of complex formation of protein molecules allowing for their domain structure
  • Mathematical modeling of histone dimers formation in vitro with solutions of different ionic strength in the presence of monovalent salts
  • Mathematical modeling of the temperature effect on binding of monomeric proteins in aqueous solutions by example on histones H2A, H2B, H3 and H4
  • Mathematical modeling of the temperature effect on binding of different sites of protein BCL-XL in aqueous solutions
  • Mathematical modeling of the phosphorylation effect on the nature formation of biological complexes P53-MDM2 and P53-P300