Mathematical Modeling of Protein Complexes

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducin...

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Main Authors: Koshlan, Tatiana, Kulikov, Kirill (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2018, 2018
Edition:1st ed. 2018
Series:Biological and Medical Physics, Biomedical Engineering
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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100 1 |a Koshlan, Tatiana 
245 0 0 |a Mathematical Modeling of Protein Complexes  |h Elektronische Ressource  |c by Tatiana Koshlan, Kirill Kulikov 
250 |a 1st ed. 2018 
260 |a Cham  |b Springer International Publishing  |c 2018, 2018 
300 |a XIV, 367 p. 65 illus., 48 illus. in color  |b online resource 
505 0 |a Introduction -- Physical methods for studying proteins -- Physical properties of amino acids and proteins -- Selection of a biological objects -- Mathematical simulation of complex formation of protein molecules allowing for their domain structure -- Mathematical modeling of histone dimers formation in vitro with solutions of different ionic strength in the presence of monovalent salts -- Mathematical modeling of the temperature effect on binding of monomeric proteins in aqueous solutions by example on histones H2A, H2B, H3 and H4 -- Mathematical modeling of the temperature effect on binding of different sites of protein BCL-XL in aqueous solutions -- Mathematical modeling of the phosphorylation effect on the nature formation of biological complexes P53-MDM2 and P53-P300 
653 |a Protein Structure 
653 |a Biomedical engineering 
653 |a Biomedical Engineering and Bioengineering 
653 |a Numerical and Computational Physics, Simulation 
653 |a Biomathematics 
653 |a Mathematical and Computational Biology 
653 |a Biological physics 
653 |a Physics 
653 |a Proteins  
653 |a Biophysics 
653 |a Biological and Medical Physics, Biophysics 
700 1 |a Kulikov, Kirill  |e [author] 
710 2 |a SpringerLink (Online service) 
041 0 7 |a eng  |2 ISO 639-2 
989 |b Springer  |a Springer eBooks 2005- 
490 0 |a Biological and Medical Physics, Biomedical Engineering 
856 |u https://doi.org/10.1007/978-3-319-98304-2?nosfx=y  |x Verlag  |3 Volltext 
082 0 |a 571.4 
520 |a This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account. At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine