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Voltage-gated Sodium Channels: Structure, Function and Channelopathies

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophy...

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Bibliographic Details
Other Authors: Chahine, Mohamed (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2018, 2018
Edition:1st ed. 2018
Series:Handbook of Experimental Pharmacology
Subjects:
Protein Structure
Human Physiology
Human Genetics
Pharmacology
Proteins 
Pharmacology/toxicology
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Preface
  • Part I
  • Evolution of voltage-gated sodium channels
  • 1. Evolutionary History of Voltage-Gated Sodium Channels
  • 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function
  • 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective
  • 4. The Cardiac Sodium Channel and Its Protein Partners
  • 5. : Posttranslational Modification of Sodium Channels
  • 6. Sodium Channel Trafficking
  • 7. pH Modulation of Voltage-Gated Sodium Channels
  • 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C
  • Part III. Drugs and toxins interactions with sodium channels
  • 9. Toxins That Affect Voltage-Gated Sodium Channels
  • 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels
  • 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
  • 12. Structural Models of Ligand-Bound Sodium Channels
  • 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7
  • Part IV. Pathophysiology of sodium channels
  • 14. Sodium Channelopathies of Skeletal Muscle
  • 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction
  • 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain
  • 17. Gating Pore Currents in Sodium Channels
  • 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells
  • 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases.

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