Summary: | The objectives of this project are to: 1. Identify and appraise the clinical and cost-effectiveness evidence pertaining to use of atypical antipsychotic (AAP) combination and high-dose treatment strategies in the defined population and to develop evidence-based optimal use recommendations for these strategies. 2. Identify current utilization of AAP combination and high-dose treatment strategies in Canada. 3. Identify current practices of physicians and patients regarding the use of AAP combination and high-dose treatment strategies in Canada. 4. Identify differences (i.e., the gaps) between optimal prescribing and use of AAP combination and high-dose treatment strategies, as well as actual current utilization and practice. 5. Identify potential barriers to optimal use of AAP combination and high-dose treatment strategies. 6. Identify key messages to encourage optimal prescribing and use of AAP combination and high-dose treatment strategies. 7. Identify effective activities and strategies (interventions), which could be directed toward a variety of audiences such as health and allied health professionals, patients, or government decision-makers, to encourage optimal prescribing and use of AAP combination therapy and high-dose treatment strategies. 8. Develop intervention tools to support optimal prescribing and use of AAP combination therapy and high-dose treatment strategies. 9. Support implementation of tools and evaluation. 10. Develop evaluation mechanisms to measure the impact of intervention tools
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