%0 eBook %M Solr-EB001272634 %E Nikiforov, Mikhail A. %I Springer New York %D 2017 %C New York, NY %G English %B Methods in Molecular Biology %@ 9781493966707 %T Oncogene-Induced Senescence : Methods and Protocols %U https://doi.org/10.1007/978-1-4939-6670-7?nosfx=y %7 1st ed. 2017 %X This book offers in a single volume a unique collection of the state-of-the-art experimental procedures utilized for the induction, detection, and modeling of this complex cellular program of oncogene-induced senescence. The book encompasses protocols for studying this multi-step program in human specimens and a variety of experimental models including cultured mammalian cells, laboratory mice, and Drosophila melanogaster, as well as offering a description of high throughput approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oncogene-Induced Senescence: Methods and Protocols represents a valuable asset for a wide audience of medical oncologists and researchers in the fields of oncology, molecular and cellular biology, biochemistry, and animal development