Studies on Experimental Toxicology and Pharmacology

This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological m...

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Bibliographic Details
Other Authors: Roberts, Stephen M. (Editor), Kehrer, James P. (Editor), Klotz, Lars-Oliver (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2015, 2015
Edition:1st ed. 2015
Series:Oxidative Stress in Applied Basic Research and Clinical Practice
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress
  • A historical perspective on oxidative stress and intracellular redox control
  • An overview of free radicals as causes and consequences of toxicity
  • Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity
  • Lipid oxidation
  • Protein oxidation and toxicology
  • Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth?
  • Glutathione and thiols
  • Reactive oxygen species as initiators and mediators of cellular signaling processes
  • Role of oxidative stress in the process of carcinogenesis
  • Part II. Agents that produce toxicity – mechanisms and therapeutic interventions
  • Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents
  • Oxidative stress and ethanol toxicity
  • Pharmaceutical agents
  • Insecticides and herbicides
  • Health effects of indoor air pollution due to cooking with biomass fuel
  • Outdoor pollutants
  • Oxidative Stress and the Inorganic Carcinogens
  • UV-induced signaling: Role of reactive oxygen species
  • Nanomaterials
  • Chemical warfare agents
  • Part III. Special topics
  • On the biochemistry of antioxidants — current aspects.-Prevention of age-related diseases — Effects of antioxidant supplements
  • The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity — a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging.
  • Oxygen toxicity: From cough to convulsion
  • Oxidative stress in reproductive toxicology
  • Toxicogenomics-based assessment of xenobiotic-induced oxidative stress
  • Aquatic and marine biology