Chemical protein synthesis total synthesis of proteins for biological research / Stephen Kent
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2008, 2008
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| Series: | Chemical biology : the role of chemistry in our fundamental understanding of biology
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- HIV-1 protease
- Electronic properties of the catalytic apparatus
- Defining the 'aspartyl proteases'
- 'Backbone engineering' HIV-1 PR
- The alpha-helix
- Ubiquitin (76 aa)
- Conformation vs. solvation effects
- Global and local structures are highly conserved
- Stability measurements of [Aaa35] ubiquitins
- Energetic contributions at helix C' position
- Erythropoietin (Epo)
- Synthetic erythropoiesis protein
- Synthetic 'glycan mimetic'
- Glycoprotein synthesis
- Molecular basis of protein function
- The synthetic challenge
- Classical solution synthesis
- Stepwise solid-phase synthesis
- Chemical protein synthesis
- Unprotected peptides
- Principles of chemical ligation
- Thioester-forming ligation
- Total synthesis of D- & L-HIV-1 protease
- Crystal structure of D-HIV-1 protease
- Native chemical ligation
- Crambin (46 aa; 6 Cys)
- CPS: current challenges