Titin 127 a protein with a complex folding landscape
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2007, 2007
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| Series: | Protein folding, aggregation and design : concepts, experiments, theories and mechanisms
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- Examination of the folding of titin 127
- Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle
- Use of a combination of protein engineering, kinetic and thermodynamic measurements, computer simulations and single molecule atomic force microscopy to understand how evolution acts on protein sequences to allow them to adapt to stressful conditions, probably explaining why immunoglobulin-like proteins are used so successfully in evolution to perform a number of functions